The occurrence of antibiotic resistant bacteria, especially pan-drug resistant bacteria may make no antibiotics available for the treatment of infectious diseases, which will lead to the emerge of post-antibiotic era. It is imperative to find new antibacterial drugs or strategies to solve the increasingly serious problem of drug resistance. The invention status and application prospect of newtype antibiotics, antimicrobial peptide, bacteriophage and traditional Chinese medicine preparation are introduced in this paper, which may provide reference for the exploration of antibacterial drugs to conquer bacteria in post-antibiotic era.