Preliminary study of relationship between aryl hydrocarbon receptor and unexplained spontaneous abortion
Online published: 2013-03-29
Supported by
Shanghai Pudong New Area Health Bureau Foundation, PW2011D-3
Objective To investigate the expression of aryl hydrocarbon receptor (AhR) in decidua and villus, and explore its relationship with unexplained spontaneous abortion. Methods Real-time PCR and Western blotting were employed to detect the expression of AhR mRNA and protein in decidua and villus of 34 patients with unexplained spontaneous abortion (abortion group), and 38 women of normal early pregnancy were served as control group. Results The expression of AhR mRNA and protein in villus was significantly higher than that in decidua in two groups (P<0.01, P<0.05). The expression of AhR mRNA and protein in decidua in abortion group was significantly higher than that in control group (P<0.01, P<0.05). The expression of AhR mRNA and protein in villus in abortion group was significantly higher than that in control group (P<0.01, P<0.05). Conclusion The expression of AhR mRNA and protein in villus is significantly higher than that in decidua, and the upregulation of expression may be associated with the pathogenesis of unexplained spontaneous abortion.
FAN Hong-jie, LU Ji-hong, YANG Bin-lie, et al . Preliminary study of relationship between aryl hydrocarbon receptor and unexplained spontaneous abortion[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2013 , 33(3) : 294 . DOI: 10.3969/j.issn.1674-8115.2013.03.008
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