Influencing factors of reproducibility on establishment of Olanzapine-induced metabolic disorder animal model
Online published: 2013-05-28
Supported by
Shanghai Pujiang Talent Program, 10PJ1408800; National Natural Science Foundation, 81171266; Shanghai Science and Technology Innovation Program, 11140900400; Foundation of the Ministry of Education of China for Returned Talents from Overseas; Shanghai Public Health Excellent Discipline Leader Program, GWDTR201230; National Natural Science Foundation of China, 81271481
Olanzapine-induced metabolic disorders have been increasingly concerned. However, the mechanism is still unknown. The establishment of an appropriate animal model to explore the mechanism is a most important way, and the stability and reproducibility of an animal model are of vital importance. In this paper, the studies on establishment of Olanzapine-induced metabolic disorder animal models are reviewed, and the influencing factors of the reproducibility of animal models are discussed, hoping to provide reference for the related research.
Key words: Olanzapine; metabolic disorder; animal model; reproducibility
ZHANG Cheng-fang, Dake Qi, CUI Dong-hong . Influencing factors of reproducibility on establishment of Olanzapine-induced metabolic disorder animal model[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2013 , 33(5) : 690 . DOI: 10.3969/j.issn.1674-8115.2013.05.037
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