Objective To investigate the application of contrast-enhanced ultrasonography in evaluation of the effect of transcatheter arterial chemoembolization (TACE) in hepatocellular carcinoma. Methods Color doppler ultrasonography and contrast-enhanced ultrasonography were performed to evaluate the blood perfusion features of 120 cases of hepatocellular carcinoma one month after TACE. The results of two imaging methods were compared. Results There was no difference in the size of tumor measured by two methods. According to the blood perfusion features, active tumors were detected in 37 cases in color doppler ultrasonography, while active tumors were determined in 46 cases in contrast-enhanced ultrasonography. Conclusion The blood vessel embolism status of tumors and the effect of TACE can be accurately and objectively revealed by contrast-enhanced ultrasonography.