上海交通大学学报(医学版) ›› 2021, Vol. 41 ›› Issue (2): 267-272.doi: 10.3969/j.issn.1674-8115.2021.02.023

• 综述 • 上一篇    

强迫症的表观遗传学研究进展

林梁俊(), 王卫娣, 王佩, 林关宁, 王振()   

  1. 上海交通大学医学院附属精神卫生中心,上海 200030
  • 收稿日期:2020-04-17 出版日期:2021-02-28 发布日期:2021-03-11
  • 通讯作者: 王振 E-mail:lj-lin@sjtu.edu.cn;wangzhen@smhc.org.cn
  • 作者简介:林梁俊(1995—),男,博士生;电子信箱:lj-lin@sjtu.edu.cn
  • 基金资助:
    上海市卫生计生系统优秀学科带头人培养计划(2017BR058);上海市教育委员会高峰高原学科建设计划(20161321)

Research progress in epigenetics of obsessive-compulsive disorder

Liang-jun LIN(), Wei-di WANG, Pei WANG, Guan-ning LIN, Zhen WANG()   

  1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Received:2020-04-17 Online:2021-02-28 Published:2021-03-11
  • Contact: Zhen WANG E-mail:lj-lin@sjtu.edu.cn;wangzhen@smhc.org.cn
  • Supported by:
    Outstanding Academic Leaders of Shanghai Health and Family Planning System(2017BR058);Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support(20161321)

摘要:

强迫症是一种致残率较高的精神疾病,其病因尚未明确。研究表明,强迫症的发生发展是基因与环境共同作用的结果。表观遗传学为解释环境因素对个体遗传的作用提供了途径及机制。目前已有报道,强迫症患者与健康人群之间存在DNA甲基化差异,而DNA甲基化水平可能与治疗效果存在密切关联。此外,研究发现强迫症患者微RNA表达丰度较健康对照上升。该文通过综述文献中关于强迫症表观遗传学的研究,总结强迫症可能的表观遗传修饰变化,有助于进一步理解强迫症发生发展的病理生理机制。

关键词: 强迫症, 表观遗传学, 遗传学, DNA甲基化, 微RNA

Abstract:

Obsessive-compulsive disorder is a high disabling psychiatric disease, with unknown etiology. Many studies have shown that the pathogenesis of obsessive-compulsive disorder is associated with both genes and the environment. Epigenetics has provided an approach to explaining the influence on individual inheritance caused by environmental factors. Nowadays, several types of research have proved that there are differences in DNA methylation between obsessive-compulsive disorder patients and healthy population, and the DNA methylation may be strongly related to treatment response. Additionally, an increased level of microRNA was found in patients with obsessive-compulsive disorder. This review summaries the studies of epigenetics of obsessive-compulsive disorder and concludes the possible changes in epigenetic modifications to further understand the pathophysiology of obsessive-compulsive disorder.

Key words: obsessive-compulsive disorder, epigenetics, genetics, DNA methylation, microRNA

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