上海交通大学学报（医学版）

上海交通大学学报（医学版）

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低促性腺激素性腺功能减退症患者助孕治疗的研究进展

江抒恬，匡延平   

  1. 上海交通大学 医学院附属第九人民医院辅助生殖科，上海 200011
  • 出版日期:2017-01-28 发布日期:2017-01-19
  • 通讯作者: 匡延平，电子信箱：kuangyanp@126.com。
  • 作者简介:江抒恬（1991—），女，博士生；电子信箱：shutiansweet@126.com。

Research progresses of the assisted reproductive techniques for hypogonadotropic hypogonadism patients

JIANG Shu-tian, KUANG Yan-ping   

  1. Department of Assisted Reproduction, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China
  • Online:2017-01-28 Published:2017-01-19

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摘要：

低促性腺激素性腺功能减退症（HH）是一种以低卵泡刺激素和低黄体生成素为特征的罕见疾病，常见表现为无青春期启动、第二性征发育缺失、闭经和不孕等，HH女性患者多需由激素替代建立月经周期、促使生殖器官发育，并于有生育要求后行促排卵治疗。目前常规的促排卵方案包括外源性促性腺激素治疗及促性腺激素释放激素脉冲治疗。对于反复促排卵失败或合并其他不孕因素的HH患者，体外受精-胚胎移植（IVF-ET）成为了一种常见的治疗手段。该文就HH患者的促排卵治疗及IVF-ET治疗两方面的研究进展进行综述。

关键词: 低促性腺激素性腺功能减退症, 排卵障碍, 促排卵, 体外受精-胚胎移植

Abstract:

Hypogonadotropic hypogonadism (HH) is a rare disease characterized by low serum follicle-stimulating hormone and low serum luteinizing hormone. An absence of puberty initiation, a lack of secondary sexual characters, amenorrhea, and infertility are the most common clinical manifestations of this disease. A hormone replaced therapy is usually needed for female HH patients in order to establish a normal menstrual cycle and prompt the development of reproductive organs. Ovulation induction then commences when fertility intention of HH patients appears. Currently the routine regimes of ovulation induction include the use of exogenous gonadotropin and pulsatile gonadotropin-releasing hormone. In-vitro fertilization and embryo transfer (IVF-ET) becomes a common treatment for HH patients suffering from repeated failure of ovulation induction or other infertile factors. This paper reviews research progresses of the ovulation induction treatment and IVF-ET treatment for HH patients.

Key words: hypogonadotropic hypogonadism, anovulation, ovulation induction, in-vitro fertilization and embryo transfer