上海交通大学学报（医学版）

上海交通大学学报（医学版）

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长链非编码RNA在乳腺癌中的研究进展

闫宁宁 1, 2，和占强 3*，徐海燕 1，张凤春 1, 2   

  1. 上海交通大学 医学院1. 附属苏州九龙医院肿瘤科，苏州 215021；2. 附属瑞金医院肿瘤科，上海 200025；3. 附属仁济医院急诊科，上海
  • 出版日期:2017-01-28 发布日期:2017-01-19
  • 通讯作者: 张凤春，电子信箱：fczhang2004@163.com。
  • 作者简介:闫宁宁（1989—），男，博士生；电子信箱：yanningrj@163.com。和占强（1990—），男，住院医师，学士；电子信箱： 916772589@qq.com。*为共同第一作者。
  • 基金资助:

    苏州市科技计划项目（SYS201062，SYS201308，SYS201404）；国家自然科学基金（81301858）

Progress of research on long noncoding RNA in breast cancer

YAN Ning-ning1, 2, HE Zhan-qiang3*, XU Hai-yan1, ZHANG Feng-chun1, 2   

  1. 1.Department of Oncology, Kowloon Hospital, Shanghai Jiao Tong University School of Medicine, Suzhou 215021, China; 2.Department of Oncology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 3.Department of Emergency, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 2000127, China
  • Online:2017-01-28 Published:2017-01-19
  • Supported by:

    Suzhou Science and Technology Project, SYS201062，SYS201308，SYS201404; National Natural Science Foundation of China, 81301858

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摘要：

随着人类基因组计划的拓展及后基因组时代的来临，人们对人类基因组结构和功能的认识不断深化。越来越多的非编码RNA（ncRNA）被发现，其中长度＞200个核苷酸的ncRNA被称为长链ncRNA（LncRNA），广泛参与了包括生长、分化、发育和凋亡在内的病理生理过程，成为肿瘤研究的新热点。乳腺癌是女性最常见的恶性肿瘤。该文就LncRNA概念及其对乳腺癌发生、发展和预后的影响作一综述。

关键词: 乳腺癌, 非编码RNA, 长链非编码RNA

Abstract:

With the expanding of human genome project and advent of post-genomic era, understanding of genome structure and function is more and more deepening. Increasing noncoding RNAs (ncRNAs) were discovered, among which longer than 200 nucleotides termed as long non-coding RNAs (LncRNAs) are involved in the pathophysiological processes including proliferation, differentiation, development, and apoptosis, becoming the new hot spots of cancer research. Breast cancer is the most common malignant tumor among women. In this article, the conception of LncRNAs and its role in occurrence, development and prognosis of breast cancer is reviewed.

Key words: breast cancer, noncoding RNA, long noncoding RNA