上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (6): 620-.

• 专题报道（抑郁障碍研究） • 上一篇    下一篇

酪氨酸激酶受体B基因多态性与抑郁症的关联性分析

洪 武, 江开达, 仇剑崟, 禹顺英, 苑成梅, 汪栋祥, 王祖承, 方贻儒   

  1. 上海交通大学 医学院附属精神卫生中心心境障碍科, 上海 200030
  • 出版日期:2010-06-25 发布日期:2010-06-28
  • 通讯作者: 方贻儒, 电子信箱: yirufang@yahoo.com.cn。
  • 作者简介:洪 武（1977—）, 女, 主治医师, 博士；电子信箱: drhongwu@126.com。
  • 基金资助:

    “十五”国家科技攻关计划（2004BA720A21-02）；国家高技术研究发展计划（“863”计划，2006AA02Z430）；上海市“登山行动计划”（064119533）；上海市卫生局青年科研基金（206Y018）

Association analysis between tyrosine kinase receptor B gene polymorphisms and major depressive disorder

HONG Wu, JIANG Kai-da, QIU Jian-ying, YU Shun-ying, YUAN Cheng-mei, WANG Dong-xiang, WANG Zu-cheng, FANG Yi-ru   

  1. Division of Mood Disorder, Shanghai Mental Health Center, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, China
  • Online:2010-06-25 Published:2010-06-28
  • Supported by:

    National Key Technologies R&D Program of “10th Five-Year Plan”, 2004BA720A21-02；Hi-Tech Research and Development Program of China, “863” Program, 2006AA02Z430；Shanghai “Climbing Mountain Action Plan” Program, 064119533；Shanghai Municipal Health Bureau Science Fund for Young Scholars, 206Y018

PDF (PC)

1663

摘要：

目的 探讨酪氨酸激酶受体（TrkB）基因多态性与抑郁症的关系。方法 收集抑郁症患者（n=237）和正常对照者（n=312）的外周静脉血，提取基因组DNA。采用TaqMan探针SNP基因分型技术检测两组TrkB基因上的两个单核苷酸多态性的基因分型，并分析基因多态性与抑郁症的关系。结果 抑郁症组与正常对照组TrkB基因rs1187272和rs993315位点基因型和等位基因分布比较，差异均无统计学意义（P>0.05）；rs1187272和rs993315位点基因型联合分析显示，两组比较差异也无统计学意义。结论 TrkB基因rs1187272和rs993315及其构成的单体型与抑郁症无显著关联，TrkB基因的多态性在抑郁症的病因学中可能不起主要作用。

关键词: 抑郁症, 酪氨酸激酶受体, 基因多态性

Abstract:

Objective To investigate the relationship between tyrosine kinase receptor B (TrkB) gene polymorphisms and major depressive disorder. Methods The samples of peripheral venous blood of 237 patients with major depressive disorder and 312 healthy controls were collected, and DNA was extracted. Two single nucleotide polymorphisms of TrkB gene were genotyped by TaqMan SNP genotyping assays, and the relationship between gene polymorphisms and major depressive disorder was explored. Results There was no significant difference in genotypes and alleles distribution of TrkB rs1187272 and rs993315 between patients with major depressive disorder and healthy controls (P>0.05). The joint analysis of rs1187272 and rs993315 revealed no significant difference between patients with major depressive disorder and healthy controls. Conclusion TrkB rs1187272 and rs993315 and their haplotypes are not significantly related to major depressive disorder, indicating that TrkB gene polymorphisms may not play important roles in the etiology of major depressive disorder.

Key words: major depressive disorder, tyrosine kinase receptor, polymorphism