上海交通大学学报（医学版）

›› 2010, Vol. 30 ›› Issue (6): 647-.

• 专题报道（抑郁障碍研究） • 上一篇    下一篇

CREB在抑郁症发病和治疗作用中的研究进展

王凌霄, 综述；彭代辉, 方贻儒, 审校   

  1. 上海交通大学 医学院附属精神卫生中心心境障碍科, 上海 200030
  • 出版日期:2010-06-25 发布日期:2010-06-28
  • 通讯作者: 方贻儒, 电子信箱: yirufang@yahoo.com.cn。
  • 作者简介:王凌霄（1981—）, 女, 住院医师, 博士生；电子信箱: wlx204189@hotmail.com。
  • 基金资助:

    上海市自然科学基金（09ZR1427200）；“十五”国家科技攻关计划（2004BA720A21-02）；国家高技术研究发展计划（“863”计划）（2006AA02Z430）

Research progress of roles of CREB in pathogenesis and treatment of depression

WANG Ling-xiao, reviewer；PENG Dai-hui, FANG Yi-ru, reviser   

  1. Division of Mood Disorder, Shanghai Mental Health Center, School of Medicine, Shanghai Jiaotong University, Shanghai 200030, China
  • Online:2010-06-25 Published:2010-06-28
  • Supported by:

    Natural Science Foundation of Shanghai, 09ZR1427200; National Key Technologies R&D Program of“10th Five-Year Plan”, 2004BA720A21-02；National High-Tech Research and Development Program of China, “863” Program, 2006AA02Z430

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摘要：

很多研究中显示，转录因子环磷腺苷反应元件结合蛋白（CREB）与抑郁症的发病机制和治疗相关。CREB是多种抗抑郁药作用过程的交汇点。长期服用抗抑郁药可以提升脑内海马CREB水平及活性，在动物模型中海马部位CREB水平和活性升高可产生抗抑郁药的效应。而在其他某些脑区内提升CREB水平则会导致类抑郁行为。该文就CREB与抑郁症发病机制和抗抑郁药起效机制的相关研究进行综述。

关键词: 环磷腺苷反应元件结合蛋白, 抑郁症, 抗抑郁药

Abstract:

The transcription factor cAMP response element-binding protein (CREB) has been implicated in relevant for pathogenesis and therapy of depression in many studies. CREB is involved in the molecular and cellular mechanism of chronic antidepressant treatment, and serves as a convergence point for multiple classes of antidepressant drugs. CREB is upregulated and activated in the hippocampus by treatment with chronic antidepressants. Increasing CREB levels in the hippocampus of rodent models results in antidepressive effects. However, increasing CREB levels in some other brain regions leads to depression-like behaviors. In this article, the roles of CREB in the pathogenesis of depression and in mediating effects of antidepressant treatment are reviewed.

Key words: cAMP response element-binding protein, depression, antidepressants