›› 2012, Vol. 32 ›› Issue (2): 168-.doi: 10.3969/j.issn.1674-8115.2012.02.009

• Original article (Clinical research) • Previous Articles     Next Articles

Macular pigment optical density and its relationship with refractive status and foveal thickness in Chinese school-aged children

ZHENG Wen-jing1, ZHANG Zheng-wei1, Kiram·Abla1, ZHU Jian-feng2, HE Xian-gui2, KE Bi-lian1   

  1. 1.Department of Ophthalmology, the First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China；2.Shanghai Eye Disease Prevention &|Treatment Center, Shanghai 200040, China
  • Online:2012-02-28 Published:2012-02-28
  • Supported by:

    Natural Science Foundation of Shanghai, 09ZR1425400；Foundation of Sight-Restoring Centre of Shanghai, 050802；Shanghai Key Laboratory for Ocular Fundus Diseases Foundation, 07Z22911

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Abstract:

Objective To investigate the macular pigment optical density (MPOD) and its relationship with refractive status and foveal thickness in Chinese school-aged children. Methods Ninety-four healthy children aged from 6 to 12 were recruited in Shanghai. MPOD was determined with heterochromatic flicker photometry, both minimum foveal thickness (MFT) and central foveal thickness (CFT) were measured by optical coherence tomography (OCT), and non-contact tonometer was used to measure intraocular pressure (IOP) followed by determination of spherical equivalent (SE) refraction after pupil dilation. Besides, body mass index (BMI) was obtained. The differences in MPOD between different genders were analysed, the correlation of MPOD with age, BMI, IOP, SE, MFT and CFT was explored, and the correlation of MPOD with MFT and CFT under different refractive status was determined. Results The mean MPOD in examined children was 0.56±0.25, with no significant difference between boys and girls (P＞0.05). There was no significant correlation of MOPD with age, BMI, IOP, SE, MFT and CFT (P>0.05 for all). In children with refractive diopter ≤－0.5 D, there was an inverse relationship between MPOD and MFT (r=－0.66，P=0.028) and a positive relationship between MPOD and CFT (r=0.67，P=0.025). Conclusion MPOD reversely correlates MFT and has a positive relationship with CFT in Chinese children aged from 6 to 12 with low to moderate myopia.

Key words: macular pigment optical density, refractive error, foveal thickness, Chinese children