• Review • Previous Articles     Next Articles

Research progress of animal models of experimental autoimmune uveitis

YU Qi, XU Xun   

  1. Department of Ophthalmology, the First People's Hospital, Shanghai Jiaotong University, Shanghai 200080, China
  • Online:2013-10-28 Published:2013-10-31
  • Supported by:

    National Natural Science Foundation of China, 81273424


Uveitis is one of the major sight-threatening diseases in ophthalmology. Animal models of experimental autoimmune uveitis (EAU) are important models for the study of uveitis and systemic autoimmune diseases. Targeting immunologically privileged retinal antigens, EAU serves as a research tool to reveal basic mechanisms as well as to evaluate novel anti-inflammatory and immunosuppressive drugs. This review details on the model induction methods, course of disease, criteria for evaluation, underlying mechanisms and research prospects.

Key words: experimental autoimmune uveitis, uveitis, effector T cells