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Advances of role of hypoxia inducible factor in acute kidney injury

WEN Dan1, ZHANG Wen2   

  1. 1.Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2.Department of Nephrology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2014-03-28 Published:2014-04-02
  • Supported by:

    Fundamental Research Key Project of Science and Technology Commission of Shanghai Municipality, 11JC1407900, 11JC1407901; “Innovation Action Plan”, Fundamental Research Major Project of Science and Technology Commission of Shanghai Municipality, 12DJ1400303

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Abstract:

Acute kidney injury (AKI) is a set of clinical syndromes characterized by acute renal function impairment. Shock, surgery, and sepsis are major pathogeneses of AKI. Hypoxia inducible factor(HIF) is a kind of transcription factor which acts as a main switch in the regulation of multiple hypoxia adaptive responses of the body. The stucture and function of HIF, and the epidemiology and pathophysiology of AKI are reviewed in this paper, and the research progress of the main role that HIF plays in AKI is analyzed.

Key words: hypoxia inducible factor, acute kidney injury, hypoxia