›› 2017, Vol. 37 ›› Issue (8): 1174-.doi: 10.3969/j.issn.1674-8115.2017.08.025

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Application of metabonomics in the diagnosis and treatment of acute kidney injury#br#

PING Feng1, GUO Yong2, LIU Yu-jing2, CAO Yong-mei2, LI Ying-chuan1   

  1. Department of Anesthesiology, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai 200233,China
  • Online:2017-08-28 Published:2017-09-28
  • Supported by:
    Shanghai Municipal Commission of Health and Family Planning Foundation for Key Developing Disciplines, 2015ZB0103

Abstract: Acute kidney injury (AKI) is the complex clinical syndrome attributed to multiple causes and risk factors, which is characterized by an abrupt loss of renal function. Metabonomics, recently advances in the field of omics, is the nontargeted measurement of all of the low-molecularweight compounds that appear in a particular cell, tissue, organ or biofluid in a living organism. Compared to genomics, transcriptomics and proteomics, metabonomics has its unique advantages, including fewer metabolites than genes, transcripts and proteins, the most accurate predictors of the signature of the actual processes, easy access to biofluids. Thus, metabonomics makes it possible to find new biomarkers for AKI on early diagnosis, identifying new metabolic pathways, finding new targets for drug therapy and individual medical treatment.

Key words: acute kidney injury, metabonomics, biomarkers, metabolic pathways