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Effects of NLRP3 inflammasome  on cerebral ischemia-reperfusion injury

GAO Li1,2, SHEN Fei1,2, LI Yan-sheng1,2   

  1. 1.Department of Neurology, Renji Hospital South Campus, Shanghai Jiao Tong University School of Medicine, Shanghai 201112, China; 2.Department of Neurology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2015-12-28 Published:2016-01-21
  • Supported by:

    Research seed training program of Renji Hospital, Shanghai Jiao Tong University, RJZZ-14-018


Ischemia-reperfusion injury is an inflammatory cascade process involving the interaction of multiple factors. In recent years, numerous studies have shown that as an important pattern recognition receptor of innate immune,  NLRP3 inflammasome involves in the inflammatory injury of cerebral ischemia-reperfusion. Thus blockage or inhibition of the activation of NLRP3 may be a new therapeutic target for the treatment of ischemic cerebrovascular diseases. However, the mechanisms of NLRP3 during the occurrence and development of cerebral ischemia are still unclear. This paper reviews the role and significance of NLRP3 inflammasome in cerebral ischemia-reperfusion injury.

Key words: cerebral ischemia, NLRP3 inflammasome, ischemia-reperfusion injury