Abstract:

The effect of progestogens in hormone replacement therapy (HRT) on risk factors of cardiovascular system diseases is attracting more and more attention. As a significant risk factor of cardiovascular diseases, blood lipid abnormality is the most common risk factor. Previous studies have confirmed that exogenous estrogen supplements are beneficial to lipids profile among peri-menopausal women. But the effect of adding progestogens into estrogen on blood lipid metabolism varies. Currently there is only a small amount of studies involve the effect of different progestogens on blood lipid metabolism. This paper reviews research progresses of effects of different progestogens on blood lipid metabolism in HRT.

Key words: hormone replacement therapy, progestogens, lipids