Abstract:

Pathological scar is a common and frequent disorder that seriously affects physical and psychological health of patients. Studies found that transforming growth factor β (TGF-β) is the most potent profibrosis factor known so far. TGF-β/Smads signal pathway is closely associated with scarring and is highlighted with inhibiting the activity of protease and matrix enzyme, as well as promoting the formation of extracellular matrixes such as collagen, and further promotes the deposition of extracellular matrixes. This paper reviews studies on prevention and treatment of pathological scar via TGF-β/Smads signal pathway and investigates better therapeutic methods.

Key words: pathological scar；transforming growth factor &beta, ； TGF-&beta, /Smads signaling pathway； therapy