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Value of Apo B and ratio of Apo AⅠ/Apo B in differential diagnosis between familial hypercholesterolemia and familial combined hyperlipidemia

YAN Li1, FU Xiao-yan1, ZHOU Shan-shan2, LIU Wei-juan3, HE Jin-xiang1,4, HE Jin-chun1,5   

  1. 1.First Clinical School of Lanzhou University, Lanzhou 730000, China； 2.Department of Laboratory Medicine, Childrens Hospital of Hebei Province, Shijiazhuang 050000, China； 3.Department of Laboratory Medicine, Peoples Hospital of Linfen, Linfen 041000, China； 4.Department of Radiotherapy, First Hospital of Lanzhou University, Lanzhou 730000, China； 5.Department of Laboratory Medicine, First Hospital of Lanzhou University, Lanzhou 730000, China
  • Online:2016-05-28 Published:2016-05-26
  • Supported by:

    National Science and Technology Major Project of the Ministry of Science and Technology of China during the“10th Five-Year Plan”，2002DA711A028-17;Science and Technology Foundation Construction of Ministry of Education，505015; Natural Science Foundation of Gansu Province，1308ＲJZA218，1302FKDA034

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Abstract:

Objective To analyze the differences in lipid levels and renal function indexes between family members with familial hypercholesterolemia (FH) and familial combined hyperlipidemia (FCHL) and investigate indexes that may be used for the differential diagnosis between FH and FCHL. Methods Six FH pedigrees (47 persons) and 23 FCHL pedigrees (94 persons) that met the diagnosis criteria and 10 normal control pedigrees (57 persons) were recruited. Persons in FH and FCHL pedigrees were assigned to the affected groups with elevated blood lipid levels and the non-affected groups with normal blood lipid levels. Blood lipid levels and renal function indexes (including CO2CP, BUN, Cr, BUN/Cr, and UA) were compared between groups.  Results The affected group in FH pedigrees had remarkably higher levels of TC, HDL-C, LDL-C, and Apo B, remarkably lower level of Apo AⅠ/Apo B, and higher levels of LP(a), BUN, Cr, and TAG as compared with the non-affected group and the control group. The differences were statistically significant. The affected group in FCHL pedigrees had remarkably higher levels of TC, TAG, LDL-C, and Apo B, remarkably lower level of Apo AⅠ/Apo B, and higher levels of HDL-C, LP(a), and BUN as compared with the non-affected group and the control group. The differences were statistically significant. The affected group in FH pedigrees had significantly higher levels of LDL-C and Apo B, higher levels of TC and Apo AⅠ/ Apo B, and significantly lower level of TAG as compared with the affected group in FCHL pedigrees. Conclusion In addition to commonly used indexes TC, TAG, and LDL-C, the Apo B level and the ratio of Apo AⅠ/Apo B are potential indexes for the differential diagnosis between FH and FCHL.

Key words: familial hypercholesterolemia, familial combined hyperlipidemia, apolipoprotein B； apolipoprotein AⅠ