• Original article (Clinical research) • Previous Articles     Next Articles

Relationship of adipose chemerin and its receptor chemerinR gene expression to obesity and type 2 diabetes mellitus

WANG Ling-yan1, YU Hao-yong2, WEI Li2   

  1. 1. Department of Endocrinology and Metabolism, Shanghai Fengxian District Central Hospital, Shanghai 201400, China; 2. Department of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University, Shanghai Diabetes Institute, Shanghai 200233, China
  • Online:2017-03-28 Published:2017-03-30
  • Supported by:

    National Natural Science Foundation of China, 30670989

Abstract:

Objective · To explore the relationship of adipose chemerin and its receptor chemerinR gene expression to obesity and type 2 diabetes mellitus. Methods · Twenty-four patients undergoing elective abdominal surgery were enrolled, and were divided into normal glucose regulation-normal weight group (NGR-NW), normal glucose regulation-overweight/obesity group (NGR-OW/OB), and type 2 diabetic overweight/obesity group (T2DMOW/OB) according to the body mass index (BMI). The levels of chemerin and chemerinR mRNA were detected by reverse transcription PCR (RT-PCR). Results · Compare to the NGR-NW group, the chemerin mRNA levels of abdominal subcutaneous and omental fat were significantly increased in the NGR-OW/OB and T2DM-OW/OB group (P<0.05). Correlation analysis showed that the chemerin mRNA levels of abdominal omental fat were positively correlated with BMI, fasting insulin (FINS), triglyceride and serum chemerin (r=0.577, r=0.561, r=0.472, r=0.623, P<0.05 for all). The chemerin mRNA levels of abdominal subcutaneous fat showed significant positive correlation with BMI, FINS and serum chemerin (r=0.692, r=0.513, r=0.497, P<0.05 for all). Conclusion · The chemerin mRNA levels of abdominal subcutaneous and omental fat were positively correlated with BMI, FINS and serum chemerin, suggesting that the chemerin gene may play a crucial role in the pathophysiological mechanism of obesity and type 2 diabetes.

Key words: chemerin gene, chemerinR gene, obesity, type 2 diabetes mellitus