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Saf pili and biofilm formation

ZENG Long-hui, MENG Guo-yu   

  1. State Key Laboratory of Medical Genomics; Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2018-02-28 Published:2018-03-09
  • Supported by:
    National Natural Science Foundation of China, 81570120, 81770142, 81370620, 31070645; The Program  for Professor of Special Appointment  (Eastern Scholar) at Shanghai  Institutions of Higher Learning; Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152504; Shanghai Municipal Education Commission Foundation, 12ZZ109; Shanghai Science and Technology Commission Foundation, 11JC1407200

Abstract: As appendages surfacing on bacterium, pili play key roles in host cell adhesion and biofilm formation. The present paper introduces the latest
structural and functional studies of Salmonella atypical pili Saf and uncovers the mechanism of Saf pili driven biofilm formation, which provides new
strategy to target bacterial biofilm related antibiotic resistance.

Key words:  Saf pili, host recognition, biofilm formation