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Molecular mechanism for telomere-binding proteins in regulating mammalian spermatogenesis

HUANG Chen-hui, LEI Ming   

  1. HUANG Chen-hui, LEI Ming
  • Online:2018-03-28 Published:2018-05-03
  • Supported by:
    National Basic Research Program of China, 2013CB910402; National Natural Science Foundation of China, 31330040, 31525007, 31500625; Strategic Priority Research Program of the Chinese Academy of Sciences, XDB08010201; Outstanding Academic Leader Program of Science and Technology Commission of Shanghai Municipality, 16XD1405000

Abstract: Telomere attachment to the nuclear envelope and telomere-led chromosomal movement allow proper homologous pairing in mammalian
meiotic prophase I. However, the molecular mechanisms for telomere meiosis-specific functions remain to be elucidated. The present review introduced
the structure basis for telomere attachment to the nuclear envelope, and revealed a new mechanism by which telomere functions in mammalian

Key words: telomere, meiosis, spermatogenesis