›› 2018, Vol. 38 ›› Issue (4): 463-.doi: 10.3969/j.issn.1674-8115.2018.04.021

• Review • Previous Articles     Next Articles

Role of phosphoglycerate mutase 1 in the occurence and development of tumor

LIANG Qian1, 2, SHEN Ying1, 2   

  1. 1. Department of Pharmacology and Chemical Biology, 2. Shanghai Collaborative Innovation Center for Translational Medicine, Shanghai Jiao Tong University School ofMedicine, Shanghai 200025, China
  • Online:2018-04-28 Published:2018-05-03
  • Supported by:
    National Natural Science Foundation of China, 81473232, 81773748; Project of Shanghai Municipal Commission of Health and Family Planning, 201440576; Foundation ofShanghai Jiao Tong University School of Medicine, 14XJ10002

Abstract: Phosphoglycerate mutase 1 (PGAM1) as one of the most important enzymes for glycolysis pathway, is highly expressed in multipletumor tissues and negatively correlated with the prognosis of cancer patients. PGAM1 catalyzes the conversion of 3-phosphoglycerate (3-PG) to2-phosphoglycerate (2-PG) in glycolysis pathway, then promoting anabolic pathways, energy generation, and maintaining redox balance during cancercell proliferation and metastasis. The small molecule PGAM1 inhibitors have emerged as a promising strategy for anti-tumor therapy. In this review, the significance of PGAM1 in tumor was reviewed and the research progress of PGAM1 inhibitors was also introduced.

Key words: aerobic glycolysis, phosphoglycerate mutase 1, 3-phosphoglycerate, 2-phosphoglycerate

CLC Number: