JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2020, Vol. 40 ›› Issue (05): 559-565.doi: 10.3969/j.issn.1674-8115.2020.05.001

• Novel coronavirus article • Previous Articles     Next Articles

Analysis of clinical features and related factors of coronavirus disease 2019 in Shanghai

QIU Cheng-hao1, LU Hong-zhou2, SONG Bing3, LING Yun2, LIU Xin-zhe1, ZHU Ting-ting1   

  1. 1. Department of Stomatology, Shanghai Public Health Clinical Center, Shanghai 201500, China; 2. Department of Infection, Shanghai Public Health Clinical Center, Shanghai 201500, China; 3. Department of Genetics, Graduate School of Biomedical Science, University of North Texas Health Science Center, Fort Worth TX76107, USA
  • Online:2020-05-28 Published:2020-05-28
  • Supported by:
    Shanghai Major Projects on Infectious Diseases (shslczdzk01102).

Abstract: Objective · To explore the common clinical features of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected local patients in Shanghai and their related influencing factors. Methods · A total of 320 patients admitted to Shanghai Public Health Clinical Center from January to March 2020 and diagnosed as having coronavirus disease 2019 (COVID-19) were selected. Clinical data of the patients were collected to analyze their characteristics. Using the statistical operation formula of R language, the correlation analysis of hospitalization days, days of increased hypersensitive C-reactive protein concentration (allergic days), days of lung CT improvement (CT days), and days required for nucleic acid turning negative with the main clinical manifestations and laboratory data was carried out. The correlation factors affecting the above four variables were analyzed. Results · Among the 320 patients, the proportions of mild type, moderate type, serious type and critical type were 6.25%, 83.44%, 6.88% and 3.44%, respectively; 91.25% of them had a history of exposure to Hubei. The proportions of fever, cough, sputum and fatigue were 79.06%, 46.56%, 21.56% and 15.31%, respectively. Spearman correlation analysis showed that the concentrations of lactate dehydrogenase, interleukin-2 (IL-2) and IL-6 were positively correlated with the above four variables, respectively (all P<0.05), albumin concentration was negatively correlated with allergic days (P=0.018), and CD4+ cell count was negatively correlated with CT days and days required for nucleic acid turning negative (both P<0.05). Stepwise multiple linear regression analysis showed that procalcitonin (PCT) concentration was negatively correlated with hospitalization days, CT days and allergic days (both P<0.05), and disease type was positively correlated with hospitalization days, allergic days, CT days and days required for nucleic acid turning negative (all P<0.05). Conclusion · Moderate type is common in the local patients in Shanghai; fever, cough and fatigue are common symptoms, and most of the patients are accompanied by lung CT abnormalities. The therapeutic effect and prognosis of these patients are closely related to disease type, concentrations of PCT and IL-6, as well as CD4+ cell count.

Key words: coronavirus disease 2019 (COVID-19), hypersensitive C-reactive protein (hs-CRP), lung CT, day required for nucleic acid turning negative, hospitalization day

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