JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2020, Vol. 40 ›› Issue (11): 1536-1539.doi: 10.3969/j.issn.1674-8115.2020.11.018

• Review • Previous Articles     Next Articles

Research progress of ovarian function regulated by ovarian material metabolism through Hippo signaling pathway

LI Jia1, 2, YUAN Shu-sheng3, CAO Xiu-ping4, WANG Xin-nan5, HUANG Jian1, 6, ZHENG Yue-hui2, 6   

  1. 1. Medical Experimental Teaching Center, Nanchang University, Nanchang 330006, China; 2. Key Laboratory of Reproductive Physiology and Pathology of Jiangxi Province, Nanchang 330006, China; 3. The Fourth Clinical Medical School of Nanchang University, Nanchang 330006, China; 4. Basic Medical School, Nanchang University, Nanchang 330006, China; 5. The Second Clinical Medical School of Nanchang University, Nanchang 330006, China; 6. Department of Reproductive Health, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518000, China
  • Online:2020-11-28 Published:2021-01-13
  • Supported by:
    Natural Science Foundation of Jiangxi Province (20192BAB215009, 20202ACB216003); Research and Training Program of Nanchang University (1003-31080002).

Abstract: Hippo signaling pathway exists in drosophila and mammals, which is mainly composed of upstream modulators, core components and downstream modulators and has physiological functions such as cell proliferation, differentiation and cell cycle. In recent years, some research has shown that the Hippo signaling pathway can participate in three major substances, including glucose metabolism, mevalonate metabolism and glutamine metabolism, either alone or in combination with the AMP-activated protein kinase (AMPK) signaling pathway and the mammalian target of rapamycin (mTOR) signaling pathway. The relationship between Hippo signaling pathway and ovarian material metabolism is a research hotspot that has emerged in recent years. In this review, we summarize research progress that the Hippo signaling pathway regulates the maturation of follicles, polycystic ovary syndrome and ovarian cancer, through either alone or in combination with the AMPK signaling pathway and the mTOR signaling pathway.

Key words: Hippo signaling pathway, ovary function, material metabolism, AMPK signaling pathway, mTOR signaling pathway

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