JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (6): 803-808.doi: 10.3969/j.issn.1674-8115.2021.06.017

• Review • Previous Articles     Next Articles

Research progress in health risk assessment of perfluorinated compounds among Chinese population

Qian YAO1(), Ying TIAN1,2()   

  1. 1.Department of Environmental Health, Shanghai Jiao Tong University School of Public Health, Shanghai 200025, China
    2.MOE and Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2021-06-28 Published:2021-06-29
  • Contact: Ying TIAN;
  • Supported by:
    National Key Research and Development Program of China(2017YFC1600500);Shanghai Jiao Tong University Discipline-Crossing of Medicine and Engineering Foundation(YG2019ZDA29)


Perfluorinated compounds (PFAS) are a new class of persistent organic pollutants that have attracted wide attention in recent years. With the increasing restrictions on PFAS in Europe and the United States, the production of PFAS is gradually transferring to China. The amount of PFAS used in China is increasing year by year, but there are no strict restrictions on the use of them. Furthermore, the safety limits are heading down in Europe and the United States. Based on the updated safety limits, studies in Chinese population have gradually indicated the potential risk of PFAS. This review summarizes the updated international safety limits, and introduces the research progress in health risk assessment of PFAS exposure in Chinese population according to different sources of exposure (diet, milk, drinking water, dust, atmosphere, placental transfer and comprehensive sources). The existing studies mainly focus on the health risk of PFAS exposure in high PFAS-polluted areas and in sensitive infant population in China, while the health risk of PFAS exposure in general population still needs to be further evaluated. It is necessary to carry out relevant work, which can provide reference for relevant government departments to formulate PFAS control standards and safety limits in line with China's national conditions as soon as possible. In addition, the future assessment research should pay more attention to complex evaluation of various sources of PFAS and the health hazards of PFAS alternatives.

Key words: perfluorinated compounds (PFAS), exposure source, health risk assessment, Chinese population, safety limit

CLC Number: