JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY (MEDICAL SCIENCE) ›› 2021, Vol. 41 ›› Issue (7): 949-952.doi: 10.3969/j.issn.1674-8115.2021.07.016

• Review • Previous Articles    

Research progress in amino acid PET imaging of pediatric brain tumors

Zi-hao LIU(), Wen-fang TANG, Hui WANG()   

  1. Department of Nuclear Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2021-07-28 Published:2021-08-03
  • Contact: Hui WANG;
  • Supported by:
    National Natural Science Foundation of China(51673116)


Brain tumor is the most common solid tumor in pediatric tumors with the highest rate of mortality. Conventional magnetic resonance imaging (MRI) indicates some limitations in diagnosis, surgical management and prognosis for pediatric brain tumors. Positron-emission tomography (PET) is an imaging technology that reflects the biological characteristics of tumors. By using the biological distribution of specific radiopharmaceuticals, PET can provide different metabolic information of the tumor and complement the morphological information of conventional MRI. Amino acid PET imaging uses the metabolism of radiolabeled amino acids in human to perform functional imaging of tumors. The benefits of amino acid PET imaging include diagnosis and grading, biopsy planning, prognosis, recurrence monitoring, and efficacy evaluation. This paper reviews the application of amino acid PET/CT and PET/MRI to pediatric brain tumors.

Key words: pediatric, brain tumor, positron emission tomography/computer tomo-graphy (PET/CT), positron emission tomography/magnetic resonance imaging (PET/MRI), L-[methyl-11C]methionine (11C-MET), O-(2-[18F] fluoroethyl)-L-tyrosine (18F-FET), 18F-fluoro-L-dihydroxy-phenylalanine(18F-DOPA)

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