Progress in the correlation between atopic dermatitis and colonization of Staphylococcus

doi:10.3969/j.issn.1674-8115.2022.11.013

Abstract

Abstract:

Atopic dermatitis (AD) is an inflammatory disease characterized by recurrent itch and skin lesion. The pathological mechanisms of AD include the immunological disorders caused by genetic variants with environment changing and the damage of skin barrier. Recent studies have found that the topical dysbiosis of skin microbiota promotes AD. Compared to the normal skin, the diversity of the microbiome in the lesion skin decreases drastically. Especially, in company with the decreased abundance of protective coagulase-negative Staphylococci (CoNS), the load of Staphylococcus aureus (S. aureus) meets apparent increase. S. aureus is an important clinical pathogen which can cause skin infection, bacteremia, etc. Among AD patients, S. aureus can aggravate the itch and lesion of skin by expressing various toxins, proteases, superantigens, etc. Monitoring the skin flora, especially the characteristics of Staphylococci, provides new ideas for the diagnosis and treatment of AD. Meanwhile, considering the difficulties that the conventional antibiotic therapy failed to reverse and maintain the microbiota of the patient with severe symptom, the application of the commensal microbiome with antimicrobial function provides a new insight into the treatment of AD.

Key words: atopic dermatitis, microbiota dysbiosis, Staphylococcus aureus, coagulase-negative Staphylococci, skin flora examination, antimicrobial therapy

CLC Number:

R378.1⁺1

NURXAT Nadira, LI Min, LIU Qian. Progress in the correlation between atopic dermatitis and colonization of Staphylococcus[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022, 42(11): 1605-1611.

Figures/Tables 1

TrendMD

References 46

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Microflora of the skin	Healthy control	AD lesion skin	AD nonlesion kin
Staphylococcus aureus	+	+++	++
CoNS	+	++	++
Malassezia spp.	+	++	+
Aerobacter sp.	+	-	+
Acinetobacter spp.	+	+	+
Brevibacterium spp.	+	+	+
Candida spp.	+	+	+
Corynebacterium spp.	+	+	+
Escherichia coil	+	+	+
Propionibacterium spp.	+	+	+
Klebsiella spp.	+/-	+	+/-
Micrococcus spp.	+/-	+/-	+/-
Proteus sp.	+/-	+/-	+/-
Salmonella spp.	+/-	+	+/-
Streptococcus spp.	+/-	+	+/-

Microflora of the skin	Healthy control	AD lesion skin	AD nonlesion kin
Staphylococcus aureus	+	+++	++
CoNS	+	++	++
Malassezia spp.	+	++	+
Aerobacter sp.	+	-	+
Acinetobacter spp.	+	+	+
Brevibacterium spp.	+	+	+
Candida spp.	+	+	+
Corynebacterium spp.	+	+	+
Escherichia coil	+	+	+
Propionibacterium spp.	+	+	+
Klebsiella spp.	+/-	+	+/-
Micrococcus spp.	+/-	+/-	+/-
Proteus sp.	+/-	+/-	+/-
Salmonella spp.	+/-	+	+/-
Streptococcus spp.	+/-	+	+/-

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