Research progress in the effects of insecticides on female reproductive health

doi:10.3969/j.issn.1674-8115.2022.12.017

Abstract

Abstract:

Insecticide is one of the main categories of pesticides used in agriculture and households, including organo-chlorine pesticide (OCP), organophosphate pesticide (OP), carbamate pesticide (CM), pyrethroid pesticide (PYR), and neonicotinoids. They are widely used for pest control in agricultural gardens and homes. The residues of insecticides have been extensively detected in the environment, and they can be enriched through multiple exposure pathways (such as drinking water, food chain) to produce adverse health effects on humans. In recent years, the potential reproductive health risk to females has attracted people's attention. There is an increasing evidence that insecticide exposure is related to female reproductive endocrine abnormalities, menstrual cycle disorders, decreased fertility, long time to pregnancy, spontaneous abortion and female internal genital diseases. However, the mechanism of the impact of pesticides on female reproductive health remains unclear. This article reviews recent epidemiological studies on the relationship between insecticides exposure and female reproductive health. This article also discusses the potential effects of insecticides on the interference of hypothalamus-pituitary-gonadal axis, oxidative stress, and germ cell apoptosis.

Key words: pesticides, insecticides, female reproduction, toxicological mechanism

CLC Number:

R114

LU Qi, ZHANG Shanyu, TIAN Ying. Research progress in the effects of insecticides on female reproductive health[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2022, 42(12): 1772-1779.

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References 77

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