Journal of Shanghai Jiao Tong University (Medical Science) ›› 2023, Vol. 43 ›› Issue (6): 755-760.doi: 10.3969/j.issn.1674-8115.2023.06.012

• Review • Previous Articles    

Research progress of integrated stress response in pathogenesis of Alzheimer's disease

SUN Hui(), JIN Hongfu, GUO Shenrui, FENG Yiyuan, YIN Yafu, WANG Hui, CHENG Weiwei()   

  1. Department of Nuclear Medicine/Institute of Cardiovascular Development and Regenerative Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Received:2023-02-21 Accepted:2023-04-18 Online:2023-06-28 Published:2023-06-28
  • Contact: CHENG Weiwei;
  • Supported by:
    National Natural Science Foundation of China(81901162);Foundation of Science and Technology Commission of Shanghai Municipality(20QA1406300)


Integrated stress response (ISR) is a cellular adaptive response induced by stress, which is strictly regulated by multiple phosphokinases, phosphatases and other proteins to maintain protein homeostasis. Studies have shown that ISR is abnormally activated in Alzheimer's disease, and targeted regulation of different proteins in ISR pathway inhibits the abnormal activation of ISR, leading to restoration of protein homeostasis and alleviation of the neuropathological changes and memory impairment in Alzheimer's disease models. These lines of evidence suggest that ISR has the potential to be a therapeutic target in Alzheimer's disease treatment. This paper reviews the abnormal activation and regulation mechanism of ISR in Alzheimer's disease and discusses the application of ISR as therapeutic targets to Alzheimer's disease models.

Key words: integrated stress response, Alzheimer disease, integrated stress response inhibitor, protein homeostasis

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