Research progress of integrated stress response in pathogenesis of Alzheimer's disease

doi:10.3969/j.issn.1674-8115.2023.06.012

Abstract

Abstract:

Integrated stress response (ISR) is a cellular adaptive response induced by stress, which is strictly regulated by multiple phosphokinases, phosphatases and other proteins to maintain protein homeostasis. Studies have shown that ISR is abnormally activated in Alzheimer's disease, and targeted regulation of different proteins in ISR pathway inhibits the abnormal activation of ISR, leading to restoration of protein homeostasis and alleviation of the neuropathological changes and memory impairment in Alzheimer's disease models. These lines of evidence suggest that ISR has the potential to be a therapeutic target in Alzheimer's disease treatment. This paper reviews the abnormal activation and regulation mechanism of ISR in Alzheimer's disease and discusses the application of ISR as therapeutic targets to Alzheimer's disease models.

Key words: integrated stress response, Alzheimer disease, integrated stress response inhibitor, protein homeostasis

CLC Number:

R742

SUN Hui, JIN Hongfu, GUO Shenrui, FENG Yiyuan, YIN Yafu, WANG Hui, CHENG Weiwei. Research progress of integrated stress response in pathogenesis of Alzheimer's disease[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2023, 43(6): 755-760.

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References 42

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