›› 2010, Vol. 30 ›› Issue (1): 80-.

• Original article (Clinical research) • Previous Articles     Next Articles

Influence of nebulized Pulmicort respules inhalation after endoscopic sinus surgery on expression of ENaC protein

JIANG Yi-ming1, JIANG Xu-cheng2, LI Ji-ping1, ZHANG Chun1, WANG Jia-dong1   

  1. 1. Shanghai Institute for Otolaryngology, Department of Otolaryngology-Head and Neck Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200001, China；2. Department of Pathology, Basic Medical College, Shanghai Jiaotong University, Shanghai 200025, China
  • Online:2010-01-26 Published:2010-01-26

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Abstract:

Objective To investigate the influence of nebulized Pulmicort respules inhalation after endoscopic sinus surgery (ESS) on the expression of epithelial Na+ channel (ENaC) protein in nasal mucosa. Methods Forty-four patients with nasal polyps undergoing ESS were randomly divided into Pulmicort respules treatment group (n=21, nebulized Pulmicort respules inhalation for 10 d after ESS) and Rhinocort control group (n=23, Rhinocort aqueous nasal spray for 10 d after ESS). All the patients were performed biopsy of membrane on the residual middle turbinate 14 d after ESS, eosinophils (Eos) and neutrophils (Neu) per hundred inflammation cells were counted under microscope during ESS and after ESS, and the expression of ENaC protein was detected by immunofluorescence assay. Results The percentages of Eos and Neu decreased in two groups after treatment, and the percentage of Neu in Pulmicort respules treatment group was significantly lower than that in Rhinocort control group (P<0.05). The expression of ENaC protein after treatment in Pulmicort respules treatment group was significantly lower than that in Rhinocort control group (P<0.01). Conclusion Application of pulmicort respules after ESS can decrease Neu infiltration and inhibit expression of ENaC protein, which can relieve acute inflammation and edema of nasal mucosa.

Key words: nasal polyp, residual middle turbinate, epithelial sodium channel, Pulmicort respules, nebulized inhalation