›› 2013, Vol. 33 ›› Issue (3): 294-.doi: 10.3969/j.issn.1674-8115.2013.03.008

• Original article (Clinical research) • Previous Articles     Next Articles

Preliminary study of relationship between aryl hydrocarbon receptor and unexplained spontaneous abortion

FAN Hong-jie1, LU Ji-hong2, YANG Bin-lie3, ZHAO Ai-min1   

  1. 1.Department of Obstetrics and Gynecology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China； 2.Department of Obstetrics and Gynecology, Shanghai Pudong New Area Gongli Hospital, Shanghai 200135, China； 3.Department of Obstetrics and Gynecology, Shanghai Pudong New Area People´s Hospital, Shanghai 201200, China
  • Online:2013-03-28 Published:2013-03-29
  • Supported by:

    Shanghai Pudong New Area Health Bureau Foundation, PW2011D-3

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Abstract:

Objective To investigate the expression of aryl hydrocarbon receptor (AhR) in decidua and villus, and explore its relationship with unexplained spontaneous abortion. Methods Real-time PCR and Western blotting were employed to detect the expression of AhR mRNA and protein in decidua and villus of 34 patients with unexplained spontaneous abortion (abortion group), and 38 women of normal early pregnancy were served as control group. Results The expression of AhR mRNA and protein in villus was significantly higher than that in decidua in two groups (P＜0.01, P＜0.05). The expression of AhR mRNA and protein in decidua in abortion group was significantly higher than that in control group (P＜0.01, P＜0.05). The expression of AhR mRNA and protein in villus in abortion group was significantly higher than that in control group (P＜0.01, P＜0.05). Conclusion The expression of AhR mRNA and protein in villus is significantly higher than that in decidua, and the upregulation of expression may be associated with the pathogenesis of unexplained spontaneous abortion.

Key words: aryl hydrocarbon receptor, unexplained spontaneous abortion, decidua, villus