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Research advances of breast cancer metastasis suppressor 1

ZHU Jia-fang1, GU Ming-min2   

  1. 1.School of Clinical Medicine, Shanghai Jiao Tong University School of Medicine， Shanghai 200025, China； 2.Department of Medical Genetics, Basic Medicine Faculty of Shanghai Jiao Tong University, Shanghai 200025, China
  • Online:2014-01-28 Published:2014-01-29

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Abstract:

Breast cancer metastasis suppressor 1 (BRMS1) serves as a tumor suppressor correlated with tumor metastasis and prognosis. The coiled-coil motifs of BRMS1 have the capability of homo-oligomerizing to form a trio of dimers and mediates physical association with the Sorting Nexin 6 (SNX6), and nuclear localization signal 2 （NLS2）is discovered critical to the suppressor function. BRMS1, by forming complexes with mSin-histone deacetylase complex (mSin:HDAC), suppresses expression or activities of multiple downstream targets including nuclear factor-kappa B (NF-κB), urokinase-type plasminogen activator (uPA), osteopontin (OPN), and epidermal growth factor receptor (EGFR) as well as metastasis-promoting miRNA, which affect metastasis of ovarian cancer, melanoma, and non-small cell lung cancer. In this article, recent advances on BRMS1 suppression metastasis are reviewed.

Key words: breast cancer metastasis suppressor 1, mSin3:histone deacetylase complex, nuclear factor-kappa B, urokinase-type plasminogen activator, osteopontin