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Research advances of breast cancer metastasis suppressor 1

ZHU Jia-fang1, GU Ming-min2   

  1. 1.School of Clinical Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2.Department of Medical Genetics, Basic Medicine Faculty of Shanghai Jiao Tong University, Shanghai 200025, China
  • Online:2014-01-28 Published:2014-01-29


Breast cancer metastasis suppressor 1 (BRMS1) serves as a tumor suppressor correlated with tumor metastasis and prognosis. The coiled-coil motifs of BRMS1 have the capability of homo-oligomerizing to form a trio of dimers and mediates physical association with the Sorting Nexin 6 (SNX6), and nuclear localization signal 2 (NLS2)is discovered critical to the suppressor function. BRMS1, by forming complexes with mSin-histone deacetylase complex (mSin:HDAC), suppresses expression or activities of multiple downstream targets including nuclear factor-kappa B (NF-κB), urokinase-type plasminogen activator (uPA), osteopontin (OPN), and epidermal growth factor receptor (EGFR) as well as metastasis-promoting miRNA, which affect metastasis of ovarian cancer, melanoma, and non-small cell lung cancer. In this article, recent advances on BRMS1 suppression metastasis are reviewed.

Key words: breast cancer metastasis suppressor 1, mSin3:histone deacetylase complex, nuclear factor-kappa B, urokinase-type plasminogen activator, osteopontin