Abstract:

Objective To investigate the efficacy of rabeprazole combined with flupentixol and melitracen (Deanxit) in the treatment of non-erosive gastroesophageal reflux disease (NERD) with depression and anxiety. Methods The diagnosis of NERD was based on the results of clinical symptoms and endoscopy. GERDQ was used to evaluate clinical symptoms. The hospital anxiety and depressive scale (HADS) was used to evaluate depression and anxiety status. Ninety patients were randomly divided into rabeprazole group (n=30), Deanxit group (n=30), and rabeprazole combined with Deanxit group (n=30). Each group was treated for six weeks. The efficacy was evaluated by the symptom scores. Results There were some effects of rabeprazole or Deanxit alone on the improvement of symptoms of NERD. Although the effect of rabeprazole was better than Deanxit, the differences for the relieving heartburn and substemal pain between two groups at time point of 1, 2, 4, and 6 week after treatment were not statistically significant (P>0.05). For relieving the acid regurgitation, rabeprazole was better than Deanxit. For relieving the symptoms of NERD, the treatment of combining rabeprazole and Deanxit (obvious effective rate of 83.33%) was better and faster than either rabeprazole (33.33%) or Deanxit (16.67%)(P<0.01). The total efficacy rate of rabeprazole and Deanxit group (100%) was higher than that of rabeprazole group (76.67%) or Deanxit group (63.33%)(P<0.01). Conclusion The efficacy of the treatment of combining rabeprazole and Deanxit for NERD with depression and anxiety is better. The results suggest that depression and anxiety have certain effects on the treatment of NERD.

Key words: rabeprazole, flupentixol and melitracen, gastroesophageal reflux disease, depression and anxiety