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Advances of carboxyl ester lipase, diabetes, and pancreatic exocrine diseases

ZHANG Rong, LIU Li-mei   

  1. Department of Endocrinology and Metabolism， Shanghai Diabetes Institute， Shanghai Sixth People's Hospital， Shanghai Jiao Tong University， Shanghai 200233， China
  • Online:2015-04-28 Published:2015-04-29
  • Supported by:

    National Natural Science Foundation of China, 81471012, 81270876, 30771022; Outstanding Academic Leaders Foundation of Science and Technology Commission of Shanghai Municipality, 10XD1403400

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Abstract:

The protein encoded by carboxyl ester lipase (CEL) gene is a kind of cholesterol ester hydrolase secreted by pancreatic acinar cells and is the only protein that is not synthesized and secreted by islet beta cells in 7 molecules relevant to the maturity-onset diabetes of the young (MODY). Mutations of the variable-number tandem repeat (VNTR) of CEL can cause the syndrome of MODY and pancreatic exocrine dysfunction, insulin-dependent diabetes mellitus (type 1 diabetes) or noninsulin-dependent diabetes mellitus (type 2 diabetes), and pancreatic exocrine diseases such as alcoholic pancreatitis. This paper reviews latest research progresses of gene mutations of CEL, diabetes, and pancreatic exocrine diseases.

Key words: carboxyl ester lipase, maturity-onset diabetes of the young, pancreatic exocrine dysfunction