Objective To investigate the job burnout and mental health situations of young employees of foreign invested enterprises in Shanghai. Methods A total of 3 555 young Han employees of foreign invested enterprises in Shanghai who had no religious beliefs were surveyed online by Maslach burnout inventory (MBI) and symptom checklist (improper items were removed) and their job burnout and mental health situations were analyzed. Results Among all employees, 64% of them experienced the job burnout and 7.5% of them were above the job burnout level Ⅱ. Scores of mental health of employees with Shanghai registered residence were lower than those of other employees (P<0.05), while scores of job burnout (except low self-efficacy dimension) were higher than those of other employees (P<0.01). The difference was significant between employees with Shanghai registered residence and employees without Shanghai registered residence or residence permit. Scores of depression and obsessive-compulsive situation of employees from different types of foreign invested enterprises were different (P<0.05). The differences of total score of job burnout and scores of emotional exhaustion and cynicism dimensions were significant (P<0.01). Conclusion The job burnout situation of young employees of foreign invested enterprises in Shanghai is serious, which is mainly reflected by the self-efficacy reduce dimension. The registered residence plays an important role in job burnout and mental health. The job burnout and mental health situations of employees without Shanghai registered residence or residence permit are poor. The mental health situation of employees with Shanghai registered residence is good, while their job burnout situation is poor.