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Observation on the efficacy of modified Qinzhu Liangxue decoction plus tazarotene gel for the treatment of blood-heat syndrome psoriasis vulgaris

WANG Jie1, XU Rong2, LI Bin2   

  1. 1. Department of Chinese Medical Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2. Department of Chinese Medical Surgery (Dermatology), Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China

  • Online:2016-11-28 Published:2016-11-29
  • Supported by:

    National Natural Science Foundation--Outstanding Youth Foundation, 30801460

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Abstract:

Objective · To observe the clinical efficacy of modified Qinzhu Liangxue decoction plus tazarotene gel for the treatment of blood-heat syndrome psoriasis vulgaris. Methods · Ninety-six patients with blood-heat syndrome psoriasis vulgaris were enrolled and randomly assigned to the control group (n=47) and the treatment group (n=49). The control group received modified Qinzhu Liangxue decoction and the treatment group received modified Qinzhu Liangxue decoction plus tazarotene gel for skin lesions. Both groups were consecutively treated for two courses (one month per course). Changes in Psoriasis Area and Severity Index (PASI), Dermatology Life Quality Index (DLQI), and serum cytokines in two groups were observed before and after treatment. Results · PASI, DLQI, TNF-α, IL-8, and IL-22 in both groups were significantly reduced after treatment, especially in the treatment group. The total effective rate in the treatment group was 81.63%, which was significantly higher than that in the control group (70.21%). Conclusion · Modified Qinzhu Liangxue decoction plus tazarotene gel have significant efficacy for the treatment of blood-heat syndrome psoriasis vulgaris. The efficacy is associated with the negative regulation of TNF-α, IL-8 and IL-22.

Key words: psoriasis vulgaris, blood-heat syndrome, modified Qinzhu Liangxue decoction, tazarotene gel