Case report of severe aplastic anemia complicated by multiple Bacillus cereus infections

doi:10.3969/j.issn.1674-8115.2025.08.016

Abstract

Abstract:

Patients with severe aplastic anemia (SAA) often present with neutropenia, and are particularly susceptible to infections, especially following immunosuppressive therapy. Bacillus cereus is a ubiquitous, opportunistic pathogen capable of colonizing healthy individuals and causing infections through various routes. Neutropenia is a common feature in many hematologic disorders, placing affected patients at higher risk for Bacillus cereus infections. This report describes a rare case of Bacillus cereus bacteremia with multiple abscesses in a patient with SAA during the neutropenic phase following immunosuppressive therapy. Given the rarity of such presentations, relevant literature was reviewed and the diagnostic and treatment process was analyzed in detail, with the aim of providing clinical insights and improving the management of similar cases.

Key words: aplastic anemia, Bacillus cereus, bacteremia, abscess

CLC Number:

R556.5

ZHOU Huiru, ZHANG Liqin, ZHANG Xiaoxing, SUN Zhijiang. Case report of severe aplastic anemia complicated by multiple Bacillus cereus infections[J]. Journal of Shanghai Jiao Tong University (Medical Science), 2025, 45(8): 1074-1078.

Figures/Tables 5

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References 17

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Antibiotic	Criteria		MIC/ (μg·mL^-1)	Result
Antibiotic	Sensitive/ (μg·mL^-1)	Resistant/(μg·mL^-1)	MIC/ (μg·mL^-1)	Result
Tetracycline	≤4	≥16	8	Mediated
Vancomycin	≤4	‒	1	Sensitive
Erythromycin	≤0.5	≥8	0.064	Sensitive
Meropenem	≤4	≥16	>32	Resistant
Gentamicin	≤4	≥16	0.19	Sensitive
Imipenem	≤4	≥16	>32	Resistant
Amikacin	≤16	≥64	1	Sensitive
Penicillin G	≤0.125	≥0.25	>32	Resistant

Antibiotic	Criteria		MIC/ (μg·mL^-1)	Result
Antibiotic	Sensitive/ (μg·mL^-1)	Resistant/(μg·mL^-1)	MIC/ (μg·mL^-1)	Result
Tetracycline	≤4	≥16	8	Mediated
Vancomycin	≤4	‒	1	Sensitive
Erythromycin	≤0.5	≥8	0.064	Sensitive
Meropenem	≤4	≥16	>32	Resistant
Gentamicin	≤4	≥16	0.19	Sensitive
Imipenem	≤4	≥16	>32	Resistant
Amikacin	≤16	≥64	1	Sensitive
Penicillin G	≤0.125	≥0.25	>32	Resistant