• Review •
SHU Meng-jun, GUO Sheng-rong
High expression of c-MET and hepatocyte growth factor (HGF) is frequently found in tumor cells. The activation of c-Met signaling pathway triggers a series of signaling cascade reaction, leads to the growth, proliferation and invasion of tumor cells, and exempts tumor cells from apoptosis. HGF is the ligand of c-Met, and affects the formation of microenvironment of tumor cells. How HGF activates c-Met and the signaling pathway of its downstream components, and how the crosstalk of the signaling pathway mediated by c-Met and the other receptors affects the drug resistance are introduced in this paper. Besides, the research progress of HGF and c-Met signaling pathway inhibitors is also reviewed.
hepatocyte growth factor,
SHU Meng-jun, GUO Sheng-rong. Research progress of c-Met signaling pathway and antagonists[J]. , doi: 10.3969/j.issn.1674-8115.2013.08.027.
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