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Relationship between dopamine receptor D4 exon Ⅲ polymorphism and the Gilles de la Tourette syndrome comorbid with depression

JI Wei-dong1,2, LI Ning3*, ZHENG Hong1, CHEN Si-lu1, YANG Chuang2, ZHOU Jia-xiu2, HUANG Xiao-qi2, YAO Jing2, GUO Tian-you2, GUO Lan-ting2, LIU Xie-he2, WU Zhi-guo4, WU Yan4, FANG Yi-ru4   

  1. 1.Shanghai Changning Mental Health Center, Shanghai 200335, China; 2.Mental Health Center, West China Hospital, Sichuan University, Chengdu 610041, China; 3.the Second Affiliated Hospital, Xinxiang Medical College, Xinxiang 453002, China; 4.Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China
  • Online:2014-04-28 Published:2014-05-13
  • Supported by:

    National Natural Science Foundation of China, 30470624; the “12th Five-year Plan” of National Key Technologies R&D Program, 2012BAI01B04; Medical Specialists Construction Project of Shanghai Changning Health Bureau,2012206001; Special Disease Contruction Project of Shanghai Changning Health Bureau,201210416; Key Project of Shanghai Women and Children Committee, 201208009; Leading Talent Construction Project of Changning District


Objective To investigate the relationship between the polymorphism of repeatable sequence of DRD4 exonⅢ 48 bp gene and depressive symptoms in children with Gilles de la Tourette syndrome (TS). Methods A total of 112 children who were diagnosed as TS according to the criteria of the Fourth Edition of Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) (the TS group) and 71 healthy children (the control group) were selected. The polymorphous points of DRD4 gene were genotyped by the amplification refractory mutation system (ARMS) polymerase chain reaction (PCR) genotyping assay method and the depressive levels of children with TS were measured by the children's depression inventory (CDI). Results Among 112 children with TS, 29 (25.9%) were diagnosed with depression. The differences of genotype frequency and allele frequency of DRD4 exonⅢ 48 bp VNTR among the TS group, comorbid depression group, and control group were not statistically significant (P>0.05). The differences of CDI scores and factor scores between 61 children who carried long repeat allele group and 51 children who carried short repeat allele group were not statistically significant (P>0.05). Conclusion The DRD4 exonⅢ 48 bp VNTR may not correlate to the TS comorbid depression.

Key words: Gilles de la Tourette syndrome, dopamine receptor D4, depressive symptom, association analysis