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Relationship between serum anti-Müllerian hormone and insulin resistance of patients with polycystic ovarian syndrome

XU Ling1,2, NIU Zhi-hong1, LI Yan1, CHENG Mei-yu1, FENG Yun1   

  1. 1.Reproductive Medicine Centre， Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2.Department of Obstetrics and Gynecology, Jiading Branch Hospital of Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 2001800, China
  • Online:2014-06-28 Published:2014-06-30
  • Supported by:

    College Subject of Jiading Branch Hospital of Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine，YYKYXM 2012-12-01

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Abstract:

Objective To investigate the correlation between the serum anti-Müllerian hormone (AMH) and the insulin resistance (IR) for patients with polycystic ovarian syndrome (PCOS). Methods Forty-nine patients who were diagnosed as PCOS were selected as the experimental group and 50 patients with tubal infertility and regular menstruation were selected as the control group. Patients with PCOS were divided into the high HOMA-IR group (n=25) and low HOMA-IR group (n=24) based on the median of homeostasis model assessment insulin resistance （HOMA-IR)index. Patients with PCOS were also divided into the overweight group (n=25, BMI≥23 kg/m2) and non-overweight group (n=24, BMI<23 kg/m2) based on the body mass index (BMI). Levels of serum AMH, reproductive hormones, and sugar metabolism indicators of patients were measured and comparisons among groups were conducted. The relationship between the level of AMH and HOMAIR was analyzed. Results The levels of serum AMH, luteinizing hormone (LH), LH/follicle-stimulating hormone (FSH), testosterone (T), INS, and HOMA-IR of the experimental group were significantly higher than those of the control group. The differences were statistically significant (P<0.05). The levels of serum AMH of the high HOMA-IR group were higher than those of the low HOMA-IR group. The differences were statistically significant (P<0.05). The HOMA-IR and the level of serum AMH of the experimental group were positively correlated (r=0.53, P<0.01). The HOMA-IR and the level of serum T of the overweight group were significantly higher than those of the non-overweight group. The differences were statistically significant (P<0.05). Conclusion The level of serum AMH of patients with PCOS significantly increases. The increase is irrelevant to BMI and is positively correlated to the level of IR.

Key words: polycystic ovarian syndrome, anti-Müllerian hormone, insulin resistance