• Original article (Basic research) • Previous Articles     Next Articles

Effects of prepubertal exposure to polybrominated diphenyl ethers on activity of enzymes in testis of male rats

SHA Tian-yu1, WANG Ying1, ZHOU Jing-zhe1, CHEN Li-mei1, ZHOU Yi-jun1,2, CHEN Guo-yuan2   

  1. 1.School of Public Health, Shanghai Jiao Tong University, Shanghai 200025, China; 2.School of Public Health, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China
  • Online:2014-08-28 Published:2014-09-02
  • Supported by:

    Natural Science Foundation of Science and Technology Commission of Shanghai Municipality, 12ZR1416100; National Innovation Program for Undergraduates of China, 201310248079； Foundation of Shanghai Jiao Tong University School of Medicine, 13XJ10005

PDF (PC)

1000

Abstract:

Objective To investigate the effects of prepubertal exposure to BDE-209 on the activity of enzymes in testis of male rats. Methods Twenty-four male SD rats were randomly divided into the BDE-209 group and control group. The BDE-209 group was further divided into the low dose group, medium dose group, and high dose group (corn oil was used as the solvent) according to the concentration of BDE-209 (2, 10, and 50 mg/kg, respectively). Rats of the BDE-209 group were given BDE-209 every other day for 30 d after 28 d of birth. Rats of the control group were given corn oil. All male SD rats were executed on day 63 after birth. Organ coefficients of testis and epididymis were calculated. The activity of enzymes in testis was detected and pathological changes of the testicle tissue were observed. Results The organ coefficients of testis and epididymis of the BDE-209 group were not significantly different from those of the control group after being exposed to BDE-209 for one month. The differences were not statistically significant (P>0.05). The activity of acid phosphatases (ACP), alkaline phosphatase (AKP), lactate dehydrogenase (LDH), and gamma-glutamyl transpeptidase (γ-GT) decreased, but the differences were not statistically significant (P>0.05). No significant histomorphological changes of the testicle tissue of all groups were observed. Conclusion The effect of prepubertal exposure to BDE-209 on the activity of enzymes in testis of male SD rats is not significant.

Key words: poly brominated diphenyl ethers, enzymes in testis, rats, testis, reproduction toxicity