›› 2018, Vol. 38 ›› Issue (2): 133-.doi: 10.3969/j.issn.1674-8115.2018.02.003

• Original article (Basic research) • Previous Articles     Next Articles

Effects of fenvalerate exposure during puberty on oxidative stress in male rat testis

ZHANG Jing-jing, ZHOU Yi-jun, HU Yi, SHI Rong, ZHANG Yan, TIAN Ying, GAO Yu   

  1. Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
  • Online:2018-02-28 Published:2018-03-09
  • Supported by:
    National Natural Science Foundation of China, 81602823; Scientific Research Program of Shanghai Municipal Commission of Health and Family Planning, 201640174; Early Life Plan funded by Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 15QT08; Developing Plan of Important Weak Disciplines from Shanghai Municipal Commission of Health and Family Planning, 2016ZB0103

Abstract: Objective · To study the effects of fenvalerate exposure during puberty on oxidative stress in rat testis. Methods · Fifty male Sprague-Dawley
(SD) rats were randomly divided into the control group (corn oil), low dose group (0.02 mg/kg fenvalerate), moderate dose group (1 mg/kg fenvalerate),
high dose group (50 mg/kg fenvalerate) and intervention group (50 mg/kg fenvalerate+100 mg/kg N-acetyl-L-cysteine), ten rats for each group, for two
months by gavage at four weeks of age. Malondialdehyde (MDA) content, activities of glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD)
in testis and testicular tissue morphology were detected. Results · Compared with the control group, the rat body weight and activities of GSH-Px and
SOD in testis were significantly decreased in high dose group while MDA content was increased (all P<0.05). Compared with the high dose group, MDA
content was decreased and GSH-Px activity was increased in the intervention group (both P<0.05). The results of testicular histology showed that with
the increasing exposure dose, the spermatogenic cells were arranged loosely, the number of layers was decreased and the inner diameter of seminiferous
tubules was increased. Conclusion · Exposure to fenvalerate during puberty may induce oxidative damage in testis tissue of male rats.

Key words: fenvalerate, male rat, testis, oxidative stress