›› 2019, Vol. 39 ›› Issue (6): 666-.doi: 10.3969/j.issn.1674-8115.2019.06.017

• Review • Previous Articles     Next Articles

Atmospheric fine particulate matter causing Alzheimers disease through olfactory bulb pathway: a review of recent studies

WANG Hao1*, JIANG Shan1*, GONG Yang-ming2, LIU Yan3, HUA Li1, DENG Xiao-bei1   

  1. 1. Shanghai Jiao Tong University School of Publish Health, Shanghai 200025, China; 2. Division of Chronic and Non-communicable Diseases, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China; 3. Department of Rehabilitation, Fenglin Street Community Health Service Center, Xuhui District, Shanghai 200030, China
  • Online:2019-06-28 Published:2019-07-26
  • Supported by:
    National Natural Science Foundation of China, 21777099; Shanghai Jiao Tong University Interdisciplinary Research Grant, YG2017QN71）。

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Abstract: With the improvement of quality of life, the life expectancy of residents is generally prolonged, and people suffering Alzheimer′s disease (AD) is increasing. Epidemiological and animal experiments have found that atmospheric particulate matter is associated with AD. This article briefly reviews the mechanisms of AD-related oxidative stress damage and neuroinflammation causedatmospheric fine particulate matter entering the brain via olfactory bulb pathway.

Key words: fine particulate matter (PM2.5), Alzheimer&, prime, s disease (AD), olfactory bulb, neuroinflammation, oxidative stress

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