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Clinicopathological significance of expressions of p27kip1 and Ki-67 in primary central nervous system germ cell tumors

GAO Yu-ping1, JIANG Ji-yao2, LIU Qiang3   

  1. 1.Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics, Center for Reproductive Medicine, 2.Department of Neurosurgery, 3.Department of Pathology, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2014-12-28 Published:2014-12-30
  • Supported by:

    Foundation of Science and Technology Commission of Shanghai Municipality，134119a9502，12DZ2260600

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Abstract:

Objective To investigate the clinicopathological significance of expressions of tumor suppressor gene p27kip1 and expression of cyclin Ki-67 in primary central nervous system germ cell tumors (CNSGCTs). Methods The expressions of p27kip1 and Ki-67 in tissues of 28 cases of primary CNSGCTs were detected by immunohistochemical method and Ki-67 labeling index (Ki-67 LI) was calculated. Results Among 28 cases of primary CNSGCTs, the p27kip1 expression of 17 cases (60.7%) was high, including 5 cases of mature teratomas, 10 cases of germinomas, 1 case of embryonal carcinoma, and 1 case of mixed GCT; and the p27kip1 expression of 11 cases (39.3%) was low, including 8 cases of germinomas, 1 case of immature teratoma, 1 case of choriocarcinoma, and 1 case of mixed GCT. The Ki-67 LI of 13 cases (46.4％) was higher than 50%; Ki-67 LI of 9 cases (32.1%) was 25%-50%; and Ki-67 LI of 6 cases (21.4%) was lower than 25%. The expression of p27kip1 and Ki-67 LI correlated with the histological types of CNSGCTs. The expression of p27kip1 did not correlate with sex, age, size of tumor, location, recurrence, prognosis, or Ki-67 LI (P>0.05). Conclusion The expression of p27kip1 is low in malignant primary CNSGCTs, which suggests that p27kip1 may involve in the formation and development of germ cell tumor by down-regulating the control point for transiting from G1 to S phase.

Key words: primary central nervous system germ cell tumors, germ cell tumors, teratoma, p27kip1, Ki-67