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Advances of GPRC6A and its regulation function of glucose homeostasis

DU Jing, BAO Yu-qian   

  1. Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China
  • Online:2015-01-28 Published:2015-01-29
  • Supported by:

    National Natural Science Foundation of China, 81170788

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Abstract:

The G protein coupled receptor family C, group 6, subtype A (GPRC6A) is a newly identified G protein coupled receptor, which involves in a broad range of physiological functions by combining with various ligands, such as calcium, basic amino acid, osteocalcin, and steroid, as well as the regulation of glucose homeostasis. Deletion of GPRC6A may cause disturbance of glucose homeostasis. Further study on GPRC6A and its regulation function of glucose homeostasis may identify a new therapeutic target for diabetes.

Key words: GPRC6A, glucose homeostasis, G protein coupled receptor, osteocalcin