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Signal transduction mechanisms of necroptosis and relevant advances in neurosurgical diseases research

LIU Tao, BAO Ying-hui, WANG Yong, JIANG Ji-yao   

  1. Department of Neurosurgery,Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
  • Online:2016-01-28 Published:2016-02-26
  • Supported by:

    National Natural Science Foundation of China, 81171166; Foundation of Science and Technology Commission of Shanghai Municipality, 11nm0503200。


Necroptosis is a new mode of cell death that starts with the form of apoptosis, performs as the necrosis-like phenotype, and is known as programmed necrosis or tumor necrosis factor-induced (TNF-induced) necrosis. The programmed necrosis plays an important role in the injury and death of neuronal cell due to some neurosurgical diseases, including craniocerebral trauma, brain tumor, and cerebrovascular diseases. The gradual understanding of signal transduction mechanisms of necroptosis and the discovery of potent specific inhibitors (such as necrostatin-1) provide new ideas for the clinical treatment of neurosurgical diseases. This paper reviews the advances in discovery and mechanisms of necroptosis.

Key words: necroptosis; , cell death; , signal transduction mechanisms, stroke; , traumatic brain injury; , brain tumor