Abstract:

Objective To investigate the significance of expressions of phosphatase 2A (CIP2A) and kinase 2 beta (CK2β) in tissues of esophageal squamous cell carcinoma (ESCC) and the effect on the prognosis of patients. Methods Immunohistochemical staining was used to detect the expressions of CIP2A and CK2β in 155 tissue samples of ESCC (experiment group) and 50 adjacent normal mucous membrane tissues (control group). The correlation between the expressions of CIP2A and CK2β and the clinical pathological parameters was analyzed. Kaplan-Meier survival analysis and Cox multivariate analysis were adopted to analyze the survival of patients with ESCC. Results The positive rates of expressions of CIP2A and CK2β in tissues of ESCC were 76.67% and 66.45%, which were remarkably higher than 16.00% and 12.00% of the control group. The differences were statistically significant (P=0.000). CIP2A was correlated with lymph node metastasis and TNM stage of patients with ESCC (P=0.005, P=0.000), while was not correlated with age, gender, histological grade, and depth of invasion. The expression of CK2β was correlated with histological grade, lymph node metastasis, and TNM stage of patients with ESCC (P=0.000,P=0.004,P=0.000), while was not correlated with age, gender, and depth of invasion. The expression of CIP2A was positively correlated with the expression of CK2β (r＝0.611,P=0.000). The overall 5-year survival rate of patients with ESCC was 23.33%. The 5-year survival rate of patients with positive expression of CIP2A was 8.11% (9/111) and that of patients with negative expression of CIP2A was 66.67% (26/39). The differences were statistically significant (P=0.000). The 5-year survival rate of patients with positive expression of CK2β was 6.06% (6/99) and that of patients with negative expression of CK2β was 56.86% (29/51). The differences were statistically significant (P=0.000). Cox multivariate analysis revealed that the TNM stage and expression levels of CIP2A and CK2β were independent risk factors of influencing the prognosis of patients with ESCC (P=0.008,P=0.013, P=0.000). Conclusion Expressions of CIP2A and CK2β are closely related with the occurrence and development of ESCC and may involve in the invasion and metastasis of ESCC. The prognosis of patients with positive expressions is poor. Combined detection of expressions of CIP2A and CK2β is vital for predicting the prognosis of patients with ESCC.

Key words: esophageal squamous cell carcinoma, CIP2A, CK2β, prognosis