Journal of Shanghai Jiao Tong University (Medical Science) ›› 2022, Vol. 42 ›› Issue (8): 1070-1080.doi: 10.3969/j.issn.1674-8115.2022.08.012

• Clinical research • Previous Articles    

Value of combined perineural lymphovascular invasion and tumor-stroma ratio in guiding the prognosis of colorecatal cancer

QIU Jiahui1,2(), CAI Qianqian2, YANG Yan2, CHENG Feichi2, QIU Zhengjun1,2(), HUANG Chen1,2()   

  1. 1.Nanjing Medical University of Shanghai General Hospital, Shanghai 211166, China
    2.Department of General Surgery, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 201600, China
  • Received:2022-03-11 Accepted:2022-07-21 Online:2022-08-28 Published:2022-10-08
  • Contact: QIU Zhengjun,HUANG Chen;;
  • Supported by:
    National Natural Science Foundation of China(82072662);Clinical Research Plan of SHDC(SHDC2020CR4022);Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support(20191425);CSCO-Youth Innovation Oncology Research Foundation(Y-Young2020-0458)


Objective ·To explore the prognosis effects of tumor-stroma ratio(TSR), perineural invasion (PNI) and lymphovascular invasion (LVI) on patients with colorectal cancer (CRC). Methods ·Data of 948 patients diagnosed with CRC in Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine from January 2014 to December 2018 were retrospectively analyzed, and according to pathological risk factors TSR, PNI and LVI, patients were divided into high risk group (n=81) and low risk group (n=867). After 1∶1 matching with SPSS software, 67 patients of the high risk group and 67 patients of the low risk group were obtained. The overall survival (OS) time was compared between patients in the high risk group and low risk group. The results were validated by using tissue microarray (TMA) dataset of 106 CRC patients from our research group. The clinical characteristics of the high risk group and low risk group were compared. Kaplan-Meier curve was used for survival analysis, and COX regression model was used to analyze the prognosis factors. Results ·Patients in the high risk group had a worse prognosis with a short median OS (27.7 months) than patients in the low risk group (31.1 months, P=0.000). The worse OS in patients with high risk group was validated in matched data and TMA dataset. Conclusion ·CRC with positive perineural lymphovascular invasion combined with high TSR is a type of CRC with poor prognosis, which can effectively make up for the defect of tumor-node-metastasis (TNM) stage in prognosis and can be used to predict postoperative disease development of CRC patients and guide treatment.

Key words: colorectal cancer, prognosis, pathology, perineural invasion, lymphovascular invasion, tumor-stroma ratio

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