Abstract:

Objective To analyze clinicopathological characteristics in patients with  oral squamous papilloma and papillary squamous cell carcinoma (PSCC). Methods Clinicopathological data of 122 patients with oral squamous papilloma and 61 patients with PSCC were retrospectively analyzed. Sex, age, lesion location, and pathological characteristics were compared between two groups. Results Most patients in both two groups were male. For the PSCC group, the average age was older as compared with the papilloma group. Ten patients (16.4%) had smoking history and 11 patients (18.0%) had drinking history in the PSCC group. Papilloma and PSCC were frequently occurred at palate (46.7%) and gingiva (29.5%), respectively. Histological examination found that PSCC had malignant cytological manifestations such as pleomorphic cells and abnormal mitotic figures. Immunohistochemical staining indicated that CKpan, CKhmw, and p53 proteins expressed positively in PSCC tissues, whereas CK8, Vim, SMA, and S-100 proteins expressed negatively. Conclusion Elderly patients with papillary lesions located at gingiva are high risk population of PSCC. Active early diagnosis and treatment measures, such as tissue biopsy and pathological examination, should be taken for this population.

Key words: oral, papilloma, papillary squamous cell carcinoma, clinical and pathologic feature