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Comparative study on efficacy of 41 ℃ or 43 ℃ mild hyperthermia with pegylated liposomal doxorubicin for treatment of rabbit VX2 tumor

DING Ang-ang1, XIONG Ping1, SHEN Guo-feng2, CHEN Ya-Zhu2   

  1. 1.Department of Ultrasound, Shanghai Ninth Peoples Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China; 2.School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200230, China
  • Online:2016-06-28 Published:2016-07-25
  • Supported by:

    National Natural Science Foundation of China， 81272567

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Abstract:

Objective To investigate the difference in efficacy between doxorubicin released by 41 ℃ and 43 ℃ mild hyperthermia (MH) triggered-pegylated liposomal doxorubicin (PLD) for the treatment of rabbit VX2 tumor. Methods Twelve rabbits with VX2 tumor transplanted into the superficial muscle of the hind limb were randomly assigned to 2 groups, i.e. the 41 ℃ MH+PLD group (n=6) and the 43 ℃ MH+PLD group (n=6). To achieve complete tumor remission, multiple high-dose administrations (5 mg/kg, once per week for 3 weeks) were given by intravenous injection. An embedded ultrasound tumor hyperthermia instrument was used to perform local MH at tumor sites for 30 min. Results At the endpoint, the 41 ℃ MH+PLD group had lower vascularization index, tumor weight, and levels of GOT, LDH and CPK in peripheral blood as compared with the 43 ℃ MH +PLD group. Conclusion In comparison with 43 ℃ MH for 30 min, 41 ℃ MH for 30 min plus PLD can significantly improve the antitumor efficacy, and reduce the systemic toxicity.

Key words: pegylated liposomal doxorubicin, mild hyperthermia, VX2 tumor model