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Application of nano drug delivery system to treatment of myocardial ischemia

XUE Xiao-mei, CAO Hui-min, YOU Sha-sha, HE Bin   

  1. Department of Anesthesiology and SICU, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Online:2016-09-28 Published:2016-10-31
  • Supported by:

    National Natural Science Foundation of China, 81470390, 81270003;Shanghai Municipal Education Commission—Gaofeng Clinical Medicine Grant Support, 20152218; Shanghai Jiao Tong University Medical Engineering Cross Project, YG2013MS20; Funding for Clinical Trial of Xinhua Hospital, 15LC07


Myocardial ischemia caused by coronary artery atherosclerosis is the major cause of cardiovascular disease death. Currently, administration of drugs is still an important strategy for myocardial ischemia therapy. Recent studies showed that nano drug delivery system can enhance the safety and efficacy of therapeutic agents and has great value in clinical application. Nano-DDS can deliver drugs via direct heart injection or intravenous injection. The “passive targeting” and “active targeting” properties of the nano-DDS facilitate the delivery of drugs to the site of ischemic myocardium, enhancing the concentration of drugs in the ischemic area, and improving the efficacy. This review summarizes recent studies on the application of nano-DDS to the treatment of myocardial ischemia.

Key words: nano-drug delivery system; myocardial ischemia; passive targeting; active targeting, clinical application